Which of the following requires a special prescription for dispensing?

Schedule II controlled substances require a special prescription for dispensing due to their high potential for abuse and the severe psychological or physical dependence they may cause. In many jurisdictions, these substances are tightly regulated by law, meaning that a specific type of prescription must be used, which is often non-renewable and must contain specific information including the prescriber’s details, the patient's information, the medication prescribed, and the quantity.

The regulatory framework also dictates how these prescriptions should be maintained and limits refills, ensuring close monitoring of their use. This system is in place to help prevent misuse and to safeguard public health, which is not a concern associated with the other options listed. Antihistamines, NSAIDs, and vitamins do not fall under the same stringent regulations as Schedule II controlled substances, allowing them to be dispensed with a standard prescription or even over-the-counter in many cases.